Analysis of lysine-targeted covalent inhibitors for GSTO1

Ye Fang

doi:10.54254/3029-0821/2025.28377

Article Information

Received: 17 October 2025

Published: 27 October 2025

DOI: https://doi.org/10.54254/3029-0821/2025.28377

Article Type: Research Article

Cite this article

Fang,Y. (2025). Analysis of lysine-targeted covalent inhibitors for GSTO1. Journal of Food Science, Nutrition and Health,4(2),46-51.

Data availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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About this Volume

Volume Title: JFSNH Vol.4

Part of Series: Journal of Food Science, Nutrition and Health

ISSN: 3029-0821 (Print) / 3029-083X (Online)

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[1]Oppong, D., Schiff, W., Shivamadhu, M. C., & Ahn, Y. H. (2023). Chemistry and biology of enzymes in protein glutathionylation.Current opinion in chemical biology, 75, 102326. https: //doi.org/10.1016/j.cbpa.2023.102326

[2]Board, P. G., Coggan, M., Chelvanayagam, G., Easteal, S., Jermiin, L. S., Schulte, G. K., Danley, D. E., Hoth, L. R., Griffor, M. C., Kamath, A. V., Rosner, M. H., Chrunyk, B. A., Perregaux, D. E., Gabel, C. A., Geoghegan, K. F., & Pandit, J. (2000). Identification, characterization, and crystal structure of the Omega class glutathione transferases.The Journal of biological chemistry, 275(32), 24798–24806. https: //doi.org/10.1074/jbc.M001706200

[3]Whitbread, A. K., Masoumi, A., Tetlow, N., Schmuck, E., Coggan, M., & Board, P. G. (2005). Characterization of the omega class of glutathione transferases.Methods in enzymology, 401, 78–99. https: //doi.org/10.1016/S0076-6879(05)01005-0

[4]Shen, N. X., Luo, M. Y., Gu, W. M., Gong, M., Lei, H. M., Bi, L., Wang, C., Zhang, M. C., Zhuang, G., Xu, L., Zhu, L., Chen, H. Z., & Shen, Y. (2024). GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma.Oncogene, 43(33), 2504–2516. https: //doi.org/10.1038/s41388-024-03096-z

[5]Dong, J., Mao, J., Wu, W., Qian, X., & Yu, Z. (2025). FTO Suppresses Proliferation and Induces Apoptosis of T98G Glioblastoma Cells via N6-methyladenosine Modification of GSTO1.Neurochemical research, 50(2), 83. https: //doi.org/10.1007/s11064-025-04334-w

[6]Xu, Y., Bankhead, A., 3rd, Tian, X., Tang, J., Ljungman, M., & Neamati, N. (2020). Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor.Cancer research, 80(17), 3692–3705. https: //doi.org/10.1158/0008-5472.CAN-20-0530

[7]Wu, X., Li, S., Liang, T., Yu, Q., Zhang, Y., Liu, J., Li, K., Liu, Z., Cui, M., Zhao, Y., Han, X., Jin, R., Tan, M., Chen, X. H., Zhao, Y., Zheng, M., Sun, Y., Zhou, L., & Lu, X. (2025). Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries.Angewandte Chemie (International ed. in English), 64(25), e202505581. https: //doi.org/10.1002/anie.202505581

[8]Xie, Y., Tummala, P., Oakley, A. J., Deora, G. S., Nakano, Y., Rooke, M., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Casarotto, M. G., Board, P. G., & Baell, J. B. (2020). Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors.Journal of medicinal chemistry, 63(6), 2894–2914. https: //doi.org/10.1021/acs.jmedchem.9b01391

[9]Sun, S., Homer, J. A., Smedley, C. J., Cheng, Q. Q., Sharpless, K. B., & Moses, J. E. (2023). Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs.Chem, 9(8), 2128–2143. https: //doi.org/10.1016/j.chempr.2023.05.013