Objective: To systematically analyze the potential therapeutic mechanism of licochalcone A against Alzheimer's disease by network pharmacology. Methods: The Comparative Toxicogenomics Database (CTD) and GeneCards database were screened, and Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the overlapping genes of Alzheimer's disease and licochalcone A, followed by Protein-Protein Interaction (PPI) analysis and visualization. Results: A total of 64 potential overlapping targets between licochalcone A and Alzheimer's disease were identified, among which CASP3, AKT1 and BCL2 were core targets with high degree values. The annotated genes were enriched in signal transduction, metabolism and immune system. Conclusion: Licochalcone A may exert anti-Alzheimer's disease effects by targeting and regulating inflammatory response, participating in biological processes such as signal transduction and energy metabolism, which provides a theoretical basis for the development of multi-target drugs for Alzheimer's disease.

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In the research area, chili pepper is not only a very popular food ingredient but also a critical cash crop. Observations indicate that many people in the local community grow peppers for their livelihood. However, a persistent challenge has been identified: peppers are often infected by severe pests and diseases, so the yield is frequently very low, causing significant financial loss to farmers. After learning about these issues, research interest in pepper cultivation has been aroused. At the same time, the huge advantages of microbial control in agriculture have been recognized; therefore, a topic related to chili peppers and microbial control was selected. The purpose of conducting this research is to understand to what extent microbial control can improve the cultivation of chili peppers, evaluate the assistance of different microorganisms in chili pepper cultivation compared to traditional methods, and assess whether these biological methods are economically and practically viable for ordinary farmers. This research synthesizes data from global studies to determine if microorganisms are a "silver bullet" or a supportive tool in modern agriculture. The author has read relevant literature and learned that the diseases and pests of peppers can be caused by multiple factors, ranging from fungal infections to insect infestations. Meanwhile, many microorganisms can also affect the growth of peppers to varying degrees, offering a sustainable alternative that does not damage the surrounding environment. At present, microbial control has been widely applied in agriculture, but there are still many people who do not understand this technology. They prefer traditional chemical prevention and control methods, instead of microbial control, due to habit and cost concerns. This research aims to compare conflicting views and make more people know the advantages and limitations of microbial control.

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Traditional Chinese Medicine (TCM) nutrition, with Yin-Yang and Five Elements, homology of medicine and food, and dietotherapy based on syndrome differentiation as its core, is the crystallization of wisdom from the in-depth integration of the TCM system and dietary culture. This paper systematically sorts out the theoretical origin, core principles and practical application of TCM nutrition, comparatively analyzes the commonalities and complementarities between the holistic concept and balance concept of TCM and modern nutrition, and explores the integration path of TCM nutrition and modern nutrition by combining the modern scientific verification of homology of medicine and food substances, nutritional intervention for chronic diseases and health management practice. The research shows that TCM nutrition emphasizes the correspondence between human and nature, visceral regulation and the priority of dietary nourishment, which is highly consistent with the concepts of balanced nutrition, precise intervention and chronic disease prevention and control in modern nutrition; the integration of the two can construct a nutritional system with both oriental characteristics and scientific evidence, providing more appropriate theoretical and practical support for national health.

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This article systematically reviews the application and research progress of integrated water and fertilizer technology in pepper production, focusing on the physiological mechanisms of this technology in improving the appearance, nutrition, flavor, and storage quality of peppers through water and fertilizer coordination and precise supply. It also analyzes its synergistic effects on increasing yield, water and fertilizer use efficiency, and economic benefits. The review reveals that current research still faces shortcomings such as insufficient analysis of physiological mechanisms and lack of standardization of technical parameters. In the future, it is necessary to strengthen mechanism exploration, promote parameter intelligence, and conduct interdisciplinary systematic research to fully leverage the potential of this technology in the green and sustainable development of the pepper industry.

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